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HypersensitivityA case study suggests cell-mediated immunity to allopurinol and oxypurinol is involved in allopurinol-induced hypersensitivity reactions. Allopurinol-induced hypersensitivity reactions tend to occur more often in the presence of renal insufficiency and/or concomitant thiazide diuretic therapy. Past experience suggested that the most frequent event following the initiation of allopurinol treatment was an increase in acute attacks of gout (average 6% in early studies). Do not use this medication if you are allergic to didanosine, or if you are also taking allopurinol (Zyloprim) or ribavirin (Rebetol, Ribasphere, Copegus Virazole). GastrointestinalA first of a kind case report, elevations in pancreatic exocrine enzyme level, new-onset type 1 diabetes mellitus, and allopurinol hypersensitivity syndrome have been reported in a 58-year-old Cambodian female. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. )generic name: allopurinol class: antigout agents, antihyperuricemic agents1 review(s)Rate It!9. Conversion to inactive 6-thiouric acid by xanthine oxidase is an important degradative pathway, and the inhibition of this pathway in patients receiving allopurinol is the basis for the azathioprine dosage reduction required in these patients (see Drug Interactions under PRECAUTIONS). Allopurinol, which decreases the quantity of urate that reaches the kidneys in addition to decreasing the concentration of urate in the blood, is recommended in these circumstances {02} {05} {06} {07}. Studies of patients with allopurinol-induced crystalluria and nephrolithiasis have revealed both urate and allopurinol/oxypurinol (allopurinol metabolite) calculi. At least 3 cases of allopurinol hypersensitivity syndrome have also been reported. There is a case report of a patient with no history of psychiatric disease whose allopurinol-associated catatonia, rash, and fever responded to steroids.

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